Definition - One of nine types of muscular dystrophy, a group of genetic, degenerative diseases primarily affecting voluntary muscles.
Cause - A mutation in any of at least 15 different genes that affect proteins necessary for muscle function.
Onset -Childhood to adulthood.
Symptoms - Weakness and wasting first affecting the muscles around the shoulders and hips (limb girdles).
Progression - Usually progresses slowly, with cardiopulmonary complications sometimes occurring in later stages of the disease.
Inheritance - Some types are autosomal dominant, meaning LGMD is inherited from one parent. Other types are autosomal recessive and occur when a faulty gene is inherited from each parent.
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